Mesothelioma - An Asbestos-Related Disease

mutagene štete DNK stanica, uključujući i one dijelove koji reguliraju stanične reprodukcije. Stanice počinju nekontrolirano umnožavati formiranje tumora.Faktori rasta potiču tumore proširiti time što je rezultiralo mesothelioma i raka pluća, ovisno o mjestu oštećenja.

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Asbestos is a group of minerals that occurs naturally in the form of tufts. These fibers can be converted into thin threads that are resistant to heat, chemicals and did not guide electricity. Generally, asbestos is a silicon based compound with several variants, such as amphibole, chrysotile ... etc.

Asbestos can be found in the construction of cement, insulation, roofing, boilers, steam pipes, hot water pipes and many other products. In the 1900s, asbestos was associated with a variety of respiratory problems, which were collectively known as asbestosis. Later, in 1950, the link between asbestos and mesothelioma was made. Asbestos is now known as one of the most potent carcinogens in the environment. However, even today, asbestos is found in many products of daily life (eg, fireproof clothing, caulk, clutch plates, brake pads ... etc)

Who are the risk of developing mesothelioma?

Asbestos is particularly dangerous for those people who work regularly with her. When asbestos-containing material is disturbed, the fibers are released into the atmosphere and people can breathe in that environment. Construction works (eg restoration of old buildings with asbestos-containing cement), Pipefitting, and other such works may be published asbestos fibers which then can be inhaled workers. Secondary exposure is also known to occur. Asbestos fibers are collected dust on the clothing and hair of workers can give their family members. It is known that exposure to as low as two months is sufficient to result in mesothelioma 30-40 years down the line.

Factors that influence the risk of developing mesothelioma

Several factors determine whether asbestos exposure will cause mesothelioma cancer in the future:

* Dose (how much asbestos inhalation)
* The duration (length of exposure to asbestos)
* Type of asbestos fibers (for mesothelioma, amphibole fibers are considered to be dangerous because they remain in the lungs longer and migrate to the mesothelial layer).
* Individual risk factors such as smoking and the conditions of the lung

How to asbestos causes mesothelioma cancer?

When inhaled, asbestos causes cells to die, causing the lungs to become scarred. Asbestos fibers are slowly working their way to the alveoli at the end of the mesothelium.

for some time now, scientists were able to determine the exact way in which asbestos fibers cause cancer. This is because of the alleged asbestos necrotic in nature (ie killing the cells). Dead cells should not multiply and form a tumor. It is only recently, in 2010, it was the paradox is resolved. Asbestos fibers cause programmed cell necrosis, which releases a molecule known as high mobility group box 1 (HMGB 1) protein. HMGB1 starts an inflammatory reaction that results in the production of mutagens and tumor growth factors.

mutagenic damage to DNA of cells, including those parts that regulate cellular reproduction. Cells begin to multiply uncontrollably forming tumora.Faktori stimulate tumor growth extended time, which resulted in mesothelioma and lung cancer, depending on the location of damage.