Chest roentgenograms Examined for Interstitial Fibrosis from Asbestos Exposure

One interesting study entitled, "In vitro cytological and cytogenetic effects of an Indian variety of chrysotile asbestos" K. Aravinda Babu, BC Lakkad, SK Nigam, DK Bhatt, AB Karnik, KN Thake, and SK Kashyap. SK Chatterjee - Environmental Research - Volume 21, Issue 2, April 1980, Pages 416-422 Here is an excerpt: "Summary - cytotoxic and cytogenetic effects of chrysotile asbestos (an Indian variety, AP-I) in vitro in Chinese hamster ovary cells tested. Chrysotile asbestos (AP-I) produces high cytoplasmic vacuolization, flattening of cells with increased size, and chromosomal aberrations. and cytological and cytogenetic studies were dose-dependent manner and period of exposure to chrysotile asbestos. "

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Another interesting study entitled "Pulmonary fibrosis, carcinoma, and ferruginous body counts in amosite asbestosworkers. Study of six cases." . Do Rogge VL, Greenberg SD, LH Seitzman, MH McGavran, GA Hurst, CG Spivey, KG Nelson, LR Hieger - Am J Clin Pathol 1980; 73 (4) :496-503 Here's an excerpt: "Tyler Asbestos Workers Program is a continuation of studies 1105 formeramosite asbestos workers. This report includes a survey of six former employees, of whom five died and hadautopsies, and one who underwent lobectomy. five of these people were exposed to asbestos for three monthsor less. There are four lung cancer and a rectal carcinoma. All were cigarette smokers. Ferruginous (asbestos) body content of the upper and lower lobes of the lungs was quantitated digestion techniques. Tissuesections of upper and lower lobes were individually quantitated for fibrosis and ferruginous bodies, and chest roentgenograms were examined for interstitial fibrosis. (Control lung tissue was obtained fromconsecutive autopsy of 52 adults who had no known occupational exposure to asbestos.) Relativelylow ferruginous body counts (less than 700 / g lung tissue) are associated with a mild degree of fibrosis, and multiple counts (more than 10,000 / g) with moderate to severe fibrosis. mild to moderate pulmonaryfibrosis could be identified in tissue sections prior to interstitial changes detectable by chestroentgenograms ."

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Another interesting study entitled "Radiological evidence of asbestos effects of American Marine Engineers" by Jones, Robert NMD, Diem, John E. Ph D.. Ziskand, Morton MMD, Rodriguez, Manuel MD, Weill. Hans MD - April 1984 - Volume 26 - Issue 4 Here is an excerpt: "Summary - Marine engineers undergoing routine annual chest roentgenography showed an unusual prevalence of pleural abnormalities, including plaques suggestive of past exposure to asbestos in the pilot study, I later comprehensive study of more than 5,000 movies males showed overall prevalence of 12% with pleural abnormalities (typical calcification or plaque or diffuse thickening of) the prevalence of films classified for pneumoconiotic small opacities was negligible -. 1.2% in the pilot study. incidence of pleural abnormalities were significantly higher in men with higher union membership, after controlling for age. Older merchant ships contains significant quantities of asbestos-containing insulation. Marine engineers often remove and re-insulation business known to produce high concentrations of airborne fibers. roentgenographic These survey results indicate a significant history of asbestos exposure ship engineering department staff ."

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Another interesting study entitled "Asbestosis in Long-Term employees Ontario asbestos-cement factory." Do Finkelstein, MM - American Journal of Respiratory and Critical Care Medicine - Vol. 125, no. 5, pp. 496-501. . 1982 Here is an excerpt: "The authors have studied the development of compensable (certified) asbestosis among 201 factory workers to asbestos-cement, which were first exposed to asbestos dust before 1960 and who were employed at least 15 years. Until July 1980, 39% of production workers and 20 % of maintenance workers developed chest compensable disability, "latent interval" generally exceeded 20 years of workers with asbestosis was found to be markedly increased mortality rates from deaths. malignancies and diseases of the respiratory system as a primary responsibility. We combined the limited air sampling data available to the individual work history to calculate the 18-year cumulative fiber exposure. the cumulative probability of certification is related to cumulative exposure and exposure-response relationship was found to be sigmoidal in shape ."

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